AT2 receptor (agtr2_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Angiotensin receptors AT2 receptor
GENE
AGTR2 (ECO:0000312|HGNC:HGNC:338})
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
K
|
G
|
N
|
S
|
T
|
L
|
A
|
T
|
T
|
10 |
S
|
K
|
N
|
I
|
T
|
S
|
G
|
L
|
H
|
F
|
20 |
G
|
L
|
V
|
N
|
I
|
S
|
G
|
N
|
N
|
E
|
30 |
S
|
T
|
L
|
N
|
C
|
S
|
Q
|
K
|
P
|
S
|
40 |
TM1 | |||||||||
D
|
K
|
H
|
L
|
D
|
A
|
I
|
P
|
I
|
L
|
50 |
Y
|
Y
|
I
|
I
|
F
|
V
|
I
|
G
|
F
|
L
|
60 |
V
|
N
|
I
|
V
|
V
|
V
|
T
|
L
|
F
|
C
|
70 |
ICL1 | TM2 | ||||||||
C
|
Q
|
K
|
G
|
P
|
K
|
K
|
V
|
S
|
S
|
80 |
I
|
Y
|
I
|
F
|
N
|
L
|
A
|
V
|
A
|
D
|
90 |
L
|
L
|
L
|
L
|
A
|
T
|
L
|
P
|
L
|
W
|
100 |
A
|
T
|
Y
|
Y
|
S
|
Y
|
R
|
Y
|
D
|
W
|
110 |
ECL1 | TM3 | ||||||||
L
|
F
|
G
|
P
|
V
|
M
|
C
|
K
|
V
|
F
|
120 |
G
|
S
|
F
|
L
|
T
|
L
|
N
|
M
|
F
|
A
|
130 |
S
|
I
|
F
|
F
|
I
|
T
|
C
|
M
|
S
|
V
|
140 |
D
|
R
|
Y
|
Q
|
S
|
V
|
I
|
Y
|
P
|
F
|
150 |
ICL2 | TM4 | ||||||||
L
|
S
|
Q
|
R
|
R
|
N
|
P
|
W
|
Q
|
A
|
160 |
S
|
Y
|
I
|
V
|
P
|
L
|
V
|
W
|
C
|
M
|
170 |
A
|
C
|
L
|
S
|
S
|
L
|
P
|
T
|
F
|
Y
|
180 |
ECL2 | |||||||||
F
|
R
|
D
|
V
|
R
|
T
|
I
|
E
|
Y
|
L
|
190 |
G
|
V
|
N
|
A
|
C
|
I
|
M
|
A
|
F
|
P
|
200 |
TM5 | |||||||||
P
|
E
|
K
|
Y
|
A
|
Q
|
W
|
S
|
A
|
G
|
210 |
I
|
A
|
L
|
M
|
K
|
N
|
I
|
L
|
G
|
F
|
220 |
I
|
I
|
P
|
L
|
I
|
F
|
I
|
A
|
T
|
C
|
230 |
Y
|
F
|
G
|
I
|
R
|
K
|
H
|
L
|
L
|
K
|
240 |
ICL3 | TM6 | ||||||||
T
|
N
|
S
|
Y
|
G
|
K
|
N
|
R
|
I
|
T
|
250 |
R
|
D
|
Q
|
V
|
L
|
K
|
M
|
A
|
A
|
A
|
260 |
V
|
V
|
L
|
A
|
F
|
I
|
I
|
C
|
W
|
L
|
270 |
P
|
F
|
H
|
V
|
L
|
T
|
F
|
L
|
D
|
A
|
280 |
ECL3 | |||||||||
L
|
A
|
W
|
M
|
G
|
V
|
I
|
N
|
S
|
C
|
290 |
TM7 | |||||||||
E
|
V
|
I
|
A
|
V
|
I
|
D
|
L
|
A
|
L
|
300 |
P
|
F
|
A
|
I
|
L
|
L
|
G
|
F
|
T
|
N
|
310 |
S
|
C
|
V
|
N
|
P
|
F
|
L
|
Y
|
C
|
F
|
320 |
H8 | |||||||||
V
|
G
|
N
|
R
|
F
|
Q
|
Q
|
K
|
L
|
R
|
330 |
S
|
V
|
F
|
R
|
V
|
P
|
I
|
T
|
W
|
L
|
340 |
C-term | |||||||||
Q
|
G
|
K
|
R
|
E
|
S
|
M
|
S
|
C
|
R
|
350 |
K
|
S
|
S
|
S
|
L
|
R
|
E
|
M
|
E
|
T
|
360 |
F
|
V
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
angiotensin III, angiotensin II, angiotensin-(1-7)